How do you administer linezolid IV?
How do you administer linezolid IV?
How to use Linezolid Solution, Intravenous. This medication is given by injection into a vein as directed by your doctor, usually every 12 hours. It should be injected slowly over 30 minutes to 2 hours. The dosage is based on your medical condition and response to treatment.
Can linezolid cause swelling?
SIDE EFFECTS: Pain/redness/swelling at the injection site may occur. Also, diarrhea, headache, nausea, vomiting, dizziness, trouble sleeping, or constipation may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.
What should I monitor while on linezolid?
Monitoring parameters include heart rate, blood pressure, blood glucose, weekly complete blood count (CBC), and visual function. Blood pressure requires close monitoring in patients with untreated hyperthyroidism.
Why inj linezolid is covered?
The main uses are infections of the skin and pneumonia although it may be used for a variety of other infections including drug-resistant tuberculosis. It is used either by injection into a vein or by mouth….Linezolid.
| Clinical data | |
|---|---|
| Bioavailability | ~100% (oral) |
| Protein binding | Low (31%) |
| Metabolism | liver (50–70%, CYP not involved) |
How fast can you run Zyvox IV?
ZYVOX I.V. Injection should be administered by intravenous infusion over a period of 30 to 120 minutes.
Is linezolid a Vesicant?
Vesicant antimicrobial defined as pH < 5 or > 9, or osmolality > 600 mosmol/L, including acyclovir, amikacin, ciprofloxacin, doxycycline, ganciclovir, gentamicin, levofloxacin, linezolid, trimethoprim-sulfamethoxazole, tobramycin, and vancomycin.
Can linezolid cause bleeding?
Check with your doctor immediately if you notice any unusual bleeding or bruising, black, tarry stools, blood in the urine or stools, or pinpoint red spots on your skin.
How is Zyvox administered?
ZYVOX I.V. Injection should be administered by intravenous infusion over a period of 30 to 120 minutes. Do not use this intravenous infusion bag in series connections. Additives should not be introduced into this solution.
How do you spike a Zyvox?
The blue port has an arrow pointing downward, signifying liquid flow. This blue port should be used to spike the bag. The white port is not intended to be used for this product as ZYVOX should not be mixed with other drugs.
What rate should I infuse Zyvox?
Usual dose: 600 mg q12 hours for 10 to 28 days.
What do you do for IV infiltration?
Treatment
- Stop the infusion.
- Remove the IV.
- Mark the outline affected area with a marker.
- Photograph the affected area.
- Apply a hot or cold compress based on the type of IV fluid infiltrated.
- Elevate the extremity.
- Inject medication into the subcutaneous tissue.
Can linezolid cause thrombocytopenia?
Thrombocytopenia (TP) is a common adverse effect of linezolid (LZD). However, risk factors for LZD-associated TP have been reported in Western patients with relatively heavy body weight.
When does thrombocytopenia occur with linezolid?
Interestingly, postmarketing studies have reported higher rates of linezolid-associated thrombocytopenia, ranging from 15% to 50%. The onset of the thrombocytopenia has been reported to range from within 7 days of starting the drug until as long as 14 days after discontinuation.
What is the infusion rate for linezolid?
Method of administration: The recommended linezolid dosage should be administered intravenously twice daily. Route of administration: Intravenous use. The solution for infusion should be administered over a period of 30 to 120 minutes.
What do I do if my IV site is infiltrated?
Your clinician will likely do the following:
- Stop the infusion.
- Remove the IV.
- Mark the outline affected area with a marker.
- Photograph the affected area.
- Apply a hot or cold compress based on the type of IV fluid infiltrated.
- Elevate the extremity.
- Inject medication into the subcutaneous tissue.
How is IV extravasation treated?
If extravasation occurs, the injection should be stopped immediately and the IV tubing disconnected. Avoid applying pressure to the site, and do not flush the line. Leave the original catheter in place, and attempt to aspirate as much of the infiltrated drug as possible.
Can linezolid cause pancytopenia?
Linezolid was discontinued considering that pancytopenia might be caused by the drug. The blood counts returned to normal in the follow-up. During the follow-up in the intensive care unit, supportive treatment was administered, because development of anemia and thrombocytopenia was not initially linked to the drug.
Can linezolid cause blood clots?
Linezolid can lower the number of white blood cells in your blood temporarily, increasing the chance of getting an infection. It can also lower the number of platelets, which are necessary for proper blood clotting.
Can Zyvox cause thrombocytopenia?
Summary: Linezolid (Zyvox) is a synthetic oxazolidinone antimicrobial agent that has been known to cause thrombocytopenia. Thrombocytopenia induced by linezolid is thought to occur via a mechanism similar to that of quinine/quinidine-induced immune-mediated platelet destruction.
Can Zyvox cause low platelets?
Unfortunately, linezolid can cause reductions in platelet counts by 36 to 94% from baseline with an incidence of 12.9% in pediatric and 3 – 24.5% in adult patients taking 600 mg twice daily.