What is the strongest iron infusion?

Oral Iron Salts and Their Elemental Iron. Among three ferrous salts, the fumarate has the highest elemental iron. A 325-mg ferrous fumarate has 108 mg iron; a 325-mg ferrous sulfate has 65 mg iron; and a 325-mg ferrous gluconate has 35 mg iron.

Which is the safest iron infusion?

Although oral iron is often viewed as front-line therapy, extensive published evidence has accumulated that IV iron is superior, in both efficacy and safety, to oral iron in many clinical situations and should be introduced much sooner in the treatment paradigm of iron-deficient patients.

Is iron dextran better than iron sucrose?

Intravenous (IV) iron is an alternative treatment for patients intolerant or non-responsive to oral formulations. Of the two most common formulations available in Canada, IV iron dextran is less expensive but may be associated with more overall ADRs compared to IV iron sucrose.

Which iron injection is best?

Iron dextran injection is used to treat iron-deficiency anemia (a lower than normal number of red blood cells due to too little iron) in people who cannot be treated with iron supplements taken by mouth. Iron dextran injection is in a class of medications called iron replacement products.

Why is Venofer given slowly?

Many people using this medication do not have serious side effects. Severe dizziness or fainting (hypotension) may occur while you are receiving IV iron. This may be helped by giving the medication more slowly or at a lower dose.

What is the difference between Venofer and feraheme?

FERAHEME was non-inferior to Venofer® (iron sucrose) in raising Hgb levels ≥2.0 g/dL at any time from baseline to Week 5. FERAHEME met the predefined criteria for non-inferiority to Venofer®. *Venofer® is an iron replacement product indicated for the treatment of iron deficiency anemia in patients with CKD.

Who should not take Venofer?

Venofer® should not be used in patients who are younger than two years of age or those who have ever experienced an allergic reaction to an iron injection. Venofer® can also be passed to your baby through breast milk.

Which iron infusion has least side effects?

Injectafer has fewer common side effects: Nausea. High blood pressure. Irritation at the infusion site.

Why is iron sucrose preferred?

Iron sucrose has the least reported number of adverse events and high molecular weight iron dextran the highest; low molecular weight iron dextran and ferric gluconate fall between these two.

Is venofer better than Injectafer?

Data showed that two 750 mg doses of Injectafer raised hemoglobin more than five 200mg doses of Venofer, with a change in hemoglobin of 1.13 g/dL for Injectafer vs. 0.92 for Venofer. These increases were statistically significant (treatment difference = 0.2).

How many Venofer infusions are needed?

Administer Venofer in 3 divided doses, given by slow intravenous infusion, within a 28 day period: 2 infusions each of 300 mg over 1.5 hours 14 days apart followed by one 400 mg infusion over 2.5 hours 14 days later.

Does Venofer increase ferritin?

Venofer demonstrated significant increases in mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), iron, TRANSFERRIN SATURATION (TSAT), and ferritin levels, while total iron binding capacity (TIBC) decreased significantly.

When should you not give Venofer?

If hypersensitivity reactions or signs of intolerance occur during administration, stop Venofer immediately. Monitor patients for signs and symptoms of hypersensitivity during and after Venofer administration for at least 30 minutes and until clinically stable following completion of the infusion.

How often can you get Venofer infusions?

Venofer® can be given as a maximum of 200mg not more than 3 times per week; doses must be 24 hours apart. Total cumulative Venofer® dose = number of 100mg ampoules for Hb increase.

How quickly does Venofer work?

It often takes 5 to 10 days after a Venofer® infusion to improve hemoglobin levels or feelings of fatigue. How many treatments will I need? Depending on the lab work results, you may need 1 to 4 Venofer® treatments. We usually schedule each treatment 5 to 14 days apart.

What is the typical course of Venofer treatment for iron deficiency?

The usual adult total treatment course of Venofer is 1000 mg. Venofer treatment may be repeated if iron deficiency reoccurs. *Administer early during the dialysis session. Venofer treatment may be repeated if necessary.

How much dextran do you give for iron infusion?

Iron Dextran dosage: The initial infusion requires a test dose of 25mg administered over 15 minutes with physician in the patient care area for the first 30 minutes of the infusion. If test dose is tolerated, then administer dose (500mg -1000mg) diluted in 250-1000 mL over 2-6 hours.

What is the normal ferritin level for Venofer?

Ferritin < 30; OR 3. Ferritin < 200 AND iron saturation < 20%. Venofer® dosage: Usually 300 mg in 250mL NS by IV infusion over 2 h. If weight < 50 kg (110 lb), consider a 200 mg dose to reduce infusion-related side effects.

What are the conditions under which an iron infusion may be split?

If the total necessary dose exceeds the maximum allowed single dose, then the administration has to be split (refer to “MTD” section in “DOSE” above). · Evidence of iron overload or hereditary disturbances in utilisation of iron. · Known serious hypersensitivity to other parenteral iron products.